Cosmetically, the Super Bee package recalls the limited-production muscle cars Dodge produced from 1968-1971. Mechanically, however, the 2012 Charger beneath that exterior remains unchanged, housing a 6.4-liter Hemi V-8 that pumps out 470 hp and 470 lb-ft of torque.
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First there is the tumor and then there's the horrible question of whether the cancerous cells will spread. Scientists increasingly believe that the structural properties of the tumor itself, such as how tightly the tumor cells are packed together, play a decisive role in the progression of the disease. In a new study, researchers show that the protein Pannexin1, known to have tumor-suppressive properties, plays an important role in keeping the cells within a tissue closely packed together, an effect that may be lost with cancer.
"In healthy tissues, the recently discovered protein Pannexin1 may be playing an important role in upholding the mechanical integrity of the tissue," said first author and Brown University M.D./Ph.D. student Brian Bao. "When we develop cancer, we lose Pannexin1 and we lose this integrity."
The results appeared in advance online in the Journal of Biological Chemistry on Jan. 20.
To conduct their research, the group at Brown University and the University of British Columbia employed a "3-D Petri dish" technology that allows investigators to watch closely how cells interact with each other, without scientists having to worry about additional interactions with surrounding scaffolding or the culture plate itself. How readily the cells form large multicellular structures therefore reflects their interactions with each other, not their in vitro surroundings.
Bao's advisor, Jeffrey Morgan, associate professor of medical science, developed the 3-D Petri dish technology. Morgan is the paper's senior author.
Cancer cells converge
Starting with rat "C6" glioma (brain tumor) cells that do not express Pannexin1, the researchers left some unaltered and engineered others to express Pannexin1. After putting the different cells into the 3-D Petri dishes and watching them interact for 24 hours, they saw that the Pannexin1 cells were able to form large multicellular tissues much faster and more tightly than the unaltered cancer cells.
To confirm that Pannexin1 was indeed causing these changes, Bao and his colleagues treated their samples with the drugs Probenecid and Carbenoxolone, which are well known inhibitors of Pannexin1. They saw that sure enough, the drugs negated Pannexin1's accelerating effect.
Then the team was ready to achieve the the study's main aim, Bao said, namely to determine how Pannexin1 was able to drive these cells to clump together faster and tighter. They found that Pannexin1 sets off a chain reaction involving the energy-carrying molecule ATP and specific receptors for it.
When all experiments were done, Bao, Morgan, and their collaborators had found that as soon as the cells touched each other, Pannexin1 channels were stimulated to open and release ATP. The ATP then bound to cell surface receptors, kicking off intracellular calcium waves that ultimately remodeled the network of a structural protein called actin. This remodeling increases the forces between the cells, driving them to bind together more tightly.
Figuring out that sequence, and Pannexin1's role in it, is perhaps the study's biggest contribution to cancer research, Bao said.
"Using their single-cell systems, others have been able to carefully study individual pieces of this cascade," he said. "We came from a different perspective. Because the strength of our assay is that we can look at gross multicellular behavior in 3-D, we could ask, 'Does this actually manifest into something tangible on the multicellular level?'"
Having gained this understanding of Pannexin1's role in the mechanics of tumors, Bao is now engaged in research to answer the obvious next questions: Does Pannexin1 affect the tumor's ability to spread and invade? When cancerous cells regain Pannexin1 expression, are they less likely to spread and leave the tumor?
###
Brown University: http://www.brown.edu/Administration/News_Bureau
Thanks to Brown University for this article.
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ST. LOUIS ? Looking around at the tens of thousands of people waving American flags and cheering, Army Maj. Rich Radford was moved that so many braved a cold January wind Saturday in St. Louis to honor people like him: Iraq War veterans.
The parade, borne out of a simple conversation between two St. Louis friends a month ago, was the nation's first big welcome-home for veterans of the war since the last troops were withdrawn from Iraq in December.
"It's not necessarily overdue, it's just the right thing," said Radford, a 23-year Army veteran who walked in the parade alongside his 8-year-old daughter, Aimee, and 12-year-old son, Warren.
Radford was among about 600 veterans, many dressed in camouflage, who walked along downtown streets lined with rows of people clapping and holding signs with messages including "Welcome Home" and "Thanks to our Service Men and Women." Some of the war-tested troops wiped away tears as they acknowledged the support from a crowd that organizers estimated reached 100,000 people.
Fire trucks with aerial ladders hoisted huge American flags in three different places along the route, with politicians, marching bands ? even the Budweiser Clydesdales ? joining in. But the large crowd was clearly there to salute men and women in the military, and people cheered wildly as groups of veterans walked by.
That was the hope of organizers Craig Schneider and Tom Appelbaum. Neither man has served in the military but came up with the idea after noticing there had been little fanfare for returning Iraq War veterans aside from gatherings at airports and military bases. No ticker-tape parades or large public celebrations.
Appelbaum, an attorney, and Schneider, a school district technical coordinator, decided something needed to be done. So they sought donations, launched a Facebook page, met with the mayor and mapped a route. The grassroots effort resulted in a huge turnout despite raising only about $35,000 and limited marketing.
That marketing included using a photo of Radford being welcomed home from his second tour in Iraq by his then-6-year-old daughter. The girl had reached up, grabbed his hand and said, "I missed you, daddy." Radford's sister caught the moment with her cellphone camera, and the image graced T-shirts and posters for the parade.
Veterans came from around the country, and more than 100 entries ? including marching bands, motorcycle groups and military units ? signed up ahead of the event, Appelbaum said.
Schneider said he was amazed how everyone, from city officials to military organizations to the media, embraced the parade.
"It was an idea that nobody said no to," he said. "America was ready for this."
All that effort by her hometown was especially touching for Gayla Gibson, a 38-year-old Air Force master sergeant who said she spent four months in Iraq ? seeing "amputations, broken bones, severe burns from IEDs" ? as a medical technician in 2003.
"I think it's great when people come out to support those who gave their lives and put their lives on the line for this country," Gibson said.
With 91,000 troops still fighting in Afghanistan, many Iraq veterans could be redeployed ? suggesting to some that it's premature to celebrate their homecoming. In New York, for example, Mayor Michael Bloomberg recently said there would be no city parade for Iraq War veterans in the foreseeable future because of objections voiced by military officials.
But in St. Louis, there was clearly a mood to thank the troops with something big, even among those opposed to the war.
"Most of us were not in favor of the war in Iraq, but the soldiers who fought did the right thing and we support them," said 72-year-old Susan Cunningham, who attended the parade with the Missouri Progressive Action Group. "I'm glad the war is over and I'm glad they're home."
Don Lange, 60, of nearby Sullivan, held his granddaughter along the parade route. His daughter was a military interrogator in Iraq.
"This is something everyplace should do," Lange said as he watched the parade.
Several veterans of the Vietnam War turned out to show support for the younger troops. Among them was Don Jackson, 63, of Edwardsville, Ill., who said he was thrilled to see the parade honoring Iraq War veterans like his son, Kevin, who joined him at the parade. The 33-year-old Air Force staff sergeant said he'd lost track of how many times he had been deployed to Iraq and Afghanistan as a flying mechanic.
"I hope this snowballs," he said of the parade. "I hope it goes all across the country. I only wish my friends who I served with were here to see this."
Looking at all the people around him in camouflage, 29-year-old veteran Matt Wood said he felt honored. He served a year in Iraq with the Illinois National Guard.
"It's extremely humbling, it's amazing, to be part of something like this with all of these people who served their country with such honor," he said.
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LOS ANGELES ? Directors Guild of America Awards regular Martin Scorsese and first-timer Michel Hazanavicius are the favorites as Hollywood's top filmmaker group prepares to hand out prizes.
Past winner Scorsese is nominated again for the guild's feature-film honor for his Paris adventure "Hugo," while Hazanavicius scored his first nomination for his silent-movie "The Artist."
Also in the running are Woody Allen for his romantic fantasy "Midnight in Paris"; David Fincher for his thriller "The Girl with the Dragon Tattoo"; and Alexander Payne for his family drama "The Descendants."
The Directors Guild Awards are one of Hollywood's most accurate forecasts for who will win at the industry's top honors, the Academy Awards, which will be handed out Feb. 26. Only six times in the 63-year history of the guild awards has the winner failed to take home the Oscar for best director, and more often than not, the film winning the best director Oscar is voted best picture.
Fincher had been the favorite going into the Directors Guild ceremony last year for "The Social Network," but Tom Hooper came away the winner for "The King's Speech." Hooper went on to win the Oscar, too, and his film also earned best picture.
This time, Fincher's the odd man out at the Directors Guild show. The other four guild nominees made the best-director cut at Tuesday's Oscar nominations, but Fincher missed out. The fifth Oscar slot went to Terrence Malick for the family chronicle "The Tree of Life."
French filmmaker Hazanavicius, whose credits include the spy spoofs "OSS 117: Cairo, Nest of Spies" and "OSS 117: Lost in Rio," had been a virtual unknown in Hollywood until "The Artist," his black-and-white throwback to early cinema that has been a favorite at earlier film honors.
"The Artist" won the Golden Globe for best musical or comedy and is considered a best-picture front-runner for the Oscars.
But Scorsese won the Globes' singular directing prize over Hazanavicius.
Unlike Hazanavicius, the other nominees all have competed for Directors Guild honors before. Scorsese earned his ninth and 10th guild nominations this season; besides feature-film, he's nominated for documentary directing for "George Harrison: Living in the Material World."
Scorsese is a past feature-film winner for 2006's "The Departed," as well as a TV drama winner a year ago for an episode of "Boardwalk Empire." The family film "Hugo" was a departure for Scorsese, known for dark crime tales, and the movie also was his first shot in 3-D.
Allen has been nominated five times and won for 1977's "Annie Hall." He had not been nominated since his 1989 "Crimes and Misdemeanors" but has been on a critical and commercial resurgence for "Midnight in Paris," his biggest hit in decades.
This was the third nomination for Fincher. Payne was nominated one time previously, for 2004's "Sideways."
Kelsey Grammer is the host for the guild ceremony, which is not televised. Awards presenters include Oscar nominees George Clooney ("The Descendants"), Michelle Williams ("My Week with Marilyn"), Gary Oldman ("Tinker Tailor Soldier Spy"), Jean Dujardin and Berenice Bejo ("The Artist"), and Octavia Spencer and Jessica Chastain ("The Help").
___
Online:
http://www.dga.org
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New York ? The Mexican-inspired restaurant chain is targeting the morning market. But can it lure customers away from McDonald's?
Taco Bell is joining a "mad scramble" of fast-food chains competing for the growing breakfast-on-the-go crowd. The Mexican-inspired franchise business announced Thursday that it is rolling out a morning menu of breakfast burritos, hash browns, cinnamon buns, and other new items in almost 800 restaurants across a dozen Western states. But Taco Bell will have to muscle customers away from breakfast king McDonald's, as well as Burger King, Wendy's, Starbucks, and Subway (another recent breakfast convert). Does Taco Bell stand a chance?
No. McDonald's has too big a head start: "Taco Bell's push may spark curiosity" ? breakfast at a taco joint? ? but it's waking up to this opportunity too late, says Jeff Reeves at MSN Money. McDonald's has owned the fast-food breakfast market for ages; 25 percent of its sales now stem from Egg McMuffins, coffee, and other a.m. fare. And with so many other fast-food giants doing their "darnedest" to get in on the action, Taco Bell won't sell enough 99-cent bacon-and-egg burritos to make a dent.
"Taco Bell to cook up breakfast burritos"
This formula might just work: Taco Bell has already "made its name as a favorite for the late-night crowd," says Katie Kindling at ABC News. Why couldn't it get early birds to "start to 'think outside the bun,'" too? The chain's "new take on breakfast" did well enough at trials in select California, Oklahoma, Arizona, and Ohio cities. And with the chain's decision to partner with "breakfast food heavyweights Cinnabon, Johnsonville, Tropicana, and Seattle's Best," lots of early risers will be tempted.
"Taco Bell muscles into breakfast market"
The move makes sense for Taco Bell, but not for you: It's hardly surprising that Taco Bell wants a share of the breakfast crowd, says Brand Skokie at Diets in Review. "Breakfast and snacks made up just about all of the restaurant industry's growth in the past five years." But the last things American citizens need is another way to get "fatter, sicker, and ever-more dependent upon their convenience foods." So "think outside the drive-through" and start your day with something healthy at home.
"Taco Bell's new breakfast 'another nail in the coffin'"
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Industrial and construction materials supplier Fastenal (Nasdaq: FAST - News) has significantly upped its market presence lately with the expansion of its industrial vending machines -- dubbed a "one-stop shop" to replenish supplies.
Although a two-year-old concept, the whole idea seems to have significantly picked up speed over the past ten months, as these machines doubled their contribution to Fastenal's fiscal 2011 sales to 16% as compared to year before.
A really good idea
Why would you go to a store and stand in the queue just to buy nuts and bolts or cutting tools when you could have a mini-shop in your very own workplace? That's exactly the question Fastenal's been trying to raise through its vending machine concept.
These machines, which stock items ranging from metal cutters and grinding disks to first-aid kits and gloves, are becoming popular with diverse industrial customers including manufacturing plants, energy providers, and construction contractors.
Customers seem to have taken a liking to this idea as it saves time and money, making inventory replenishment much more convenient. Automatic billing saves administrative and processing time too, while inventory levels are monitored by Internet-based software, which alerts Fastenal when supplies reach a certain low level. The restocking is done through a local store.
By the end of 2011, a total of 7,500 machines had been installed at customer locations, up from 1,925 machines just a year earlier. In fact, Fastenal's base of installed machines increased by an impressive 32% in the recent fourth quarter as compared to the third.
A smart way to save costs
The vending machines are fast reducing Fastenal's need to open new stores to drive sales, thus saving on costs. In the recent past, the company has been increasing its store count by 14% each year. However, thanks to the vending machine expansions, the company need to add just 5% more, 122 new stores, in 2011. It is almost like Fastenal is opening small stores in client locations themselves.
As a matter of fact, analyst Ryan Merkel from William Blair & Co. believes the introduction of these vending machines could be the largest "land-grab opportunity" in distribution of industrial supplies in the past 20 years. The implementation of this strategy is certainly helping to keep Fastenal one step ahead of industry competitors such as W.W. Grainger (NYSE: GWW - News), which posted revenue growth of only 3.8% over the past three years.
Fastenal's fast figures
The company plans to install 10,000 vending machines each year over the next few years, and it definitely seems capable of doing so. This debt-free company has an impressive unlevered free cash flow of $138 million in addition to their encouraging recent performance.
In every quarter of 2011, Fastenal saw over 20% revenue growth. The company's earnings per share also met Street expectations all throughout the year. And in the latest quarter, Fastenal's profits increased by 34%, to $87.5 million, compared to last year.
Future proof
Fastenal's management plans to promote these machines aggressively in the future using selling incentives and new software, which could be more cost effective for end users. Overall, I'm feeling good about Fastenal's future.
To keep an eye on this stock, click here to add it to your Watchlist. It's free!
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CANBERRA, Australia ? A clash between protesters and Australian police that forced bodyguards to rush Prime Minister Julia Gillard out of an event appears to have been set off by information released by one of Gillard's own aides.
The aide, media adviser Tony Hodges, resigned. Gillard's office said Friday that he told someone that opposition leader Tony Abbott would be at the awards ceremony where the clash occurred. A spokesperson said in a statement that the information was passed on to indigenous-rights protesters who were demonstrating nearby.
The protesters were angry about comments Abbott made about their movement, and about 200 of them surrounded the Canberra restaurant where the ceremony was being held. Gillard stumbled as she was rushed out and lost a shoe, which the protesters picked up.
Gillard said Saturday that Hodges acted alone, and that she accepted his resignation because she considered his conduct unacceptable. She said she was upset that protesters disrupted the awards ceremony, which honored Australians for their service and courage during recent natural disasters.
Abbott on Saturday demanded more details and an investigation into what he called a "serious security breach." He told Sky News the incident appeared to be an attempt to "trigger something potentially dire for political advantage."
"Trouble was triggered and it seems that someone from the prime minister's office had a very big hand in all of that," he said.
Gillard said the suggestion that she played a role in the clash was "deeply offensive" and added that "it is absolutely typical of Mr Abbott's negativity and his tendency to go too far."
The restaurant where Thursday's clash occurred is close to the so-called Aboriginal Tent Embassy, where the protesters had demonstrated peacefully earlier in the day. That long-standing, ramshackle collection of tents and temporary shelters is a center point of protests against Australia Day, which marks the arrival of the first fleet of British colonists in Sydney on Jan. 26, 1788.
The Tent Embassy celebrated its 40th anniversary on Thursday, and Abbott had earlier angered activists by saying it was time the embassy "moved on." Abbott said Friday that his comment had been misinterpreted, and that he never meant to imply the embassy should be torn down.
The blue suede shoe Gillard lost was handed to a security guard at Parliament House late Friday and taken to her office.
(This version corrects that adviser resigned rather than was fired.)
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French President Nicolas Sarkozy, right, welcomes Afghan President Hamid Karzai, left, at the Elysee Palace, in Paris, Friday Jan. 27, 2012. (AP Photo/Thibault Camus)
French President Nicolas Sarkozy, right, welcomes Afghan President Hamid Karzai, left, at the Elysee Palace, in Paris, Friday Jan. 27, 2012. (AP Photo/Thibault Camus)
French President Nicolas Sarkozy, right, welcomes Afghan President Hamid Karzai, left, at the Elysee Palace, in Paris, Friday Jan. 27, 2012. (AP Photo/Thibault Camus)
French President Nicolas Sarkozy, right, waits prior to welcoming Afghan President Hamid Karzai, unseen, at the Elysee Palace, in Paris, Friday Jan. 27, 2012. (AP Photo/Thibault Camus)
PARIS (AP) ? France and Afghanistan will ask NATO to hand over all combat missions to the Afghan military in 2013, a year earlier than planned, President Nicolas Sarkozy said Friday.
It signaled a sharp break by France, the fourth-largest troop contributor in Afghanistan, from its previous plans to adhere to the U.S. goal of withdrawing combat forces by the end of 2014. The proposal was made a week after four unarmed French troops were killed by an Afghan soldier described as a Taliban infiltrator.
Sarkozy, who made the announcement during a visit by Afghan President Hamid Karzai, said France has informed President Barack Obama of the plan, and will present it at a Feb. 2-3 meeting of NATO defense ministers in Brussels. Sarkozy said he was planning a phone call with Obama on the matter Saturday.
"We have decided in a common accord with President Karzai to ask NATO to consider a total handing of NATO combat missions to the Afghan army over the course of 2013," he said.
The French leader also announced his country's troops will withdraw by the end of 2013 and restart training missions Saturday. Last week, Sarkozy suspended France's training missions and joint military patrols with Afghan forces following the shooting death of the four French troops on Jan. 20.
A sense of widespread fatigue has been growing among European contributors to the 10-year allied intervention in Afghanistan. The latest idea floated by Sarkozy would accelerate a gradual drawdown of NATO troops that Obama has planned to see through until the end of 2014.
France's announcement could step up pressure in other European governments like Britain, Italy and Germany, which also have important roles in Afghanistan ? even if the U.S. has the lion's share by far.
In Washington, U.S. State Department spokeswoman Victoria Nuland said the timetable announced by France was worked through by both the Afghans and NATO as part of efforts to transfer security authority to Afghanistan.
"We, obviously, want to continue to work together to ensure that this is implemented in a way that is consistent with the efforts of all of NATO to give increasing authority to the Afghans, and that it is smooth," she said.
Nuland said the U.S. was pleased the move was not "precipitous."
"So you know, this was a national decision of France. It was done in a managed way. We will all work with it. As the president has said, with regard to our own presence, we are working on 2014," she said.
"The alliance as a whole is working on 2014. But we are also going to work within this French decision," she added.
NATO reacted tersely to Sarkozy's statement.
"We have taken note of the statement," NATO spokeswoman Oana Lungescu said in Brussels.
Sarkozy also said France will speed up its own withdrawal timetable, pulling out 1,000 of its current 3,600 soldiers by year-end ? the previous target was 600 ? and bring all combat forces out by the end of 2013.
Karzai had said previously that the goal was to have Afghan security forces in charge of security across the entire nation by the end of 2014. Afghan forces started taking the lead for security in certain areas of the country last year and the plan has been to add more areas, as Afghan police and soldiers were deemed ready to take over from foreign forces.
According to drawdown plans already announced by the U.S. and more than a dozen other nations, the foreign military footprint in Afghanistan will shrink by an estimated 40,000 troops at the close of this year. Washington is pulling out the most ? 33,000 by the end of the year. That's one-third of 101,000 U.S. troops that were in Afghanistan in June, the peak of the U.S. military presence in the war, Pentagon figures show.
With Karzai at his side, Sarkozy also said France would hand over authority in the strategic province of Kapisa east of Kabul, where nearly all French troops are deployed, to the Afghans in March.
"A new phase is starting with the Afghans in which civilian and development projects will progressively take the handoff from our military presence," Sarkozy said, adding Afghan security "is the business of Afghans."
Karzai, who praised the role of France and other NATO allies, didn't object when Sarkozy said the 2013 timetable was sought by the two countries.
But the Afghan leader appeared to suggest that it was a high-end target.
"Yes, Mr. President, it is right that Afghanistan has to provide for its own security and for the protection of its own people, and for the provision of law and order," Karzai told Sarkozy.
"We hope to finish the transition ? to complete this transition of authority to the Afghan forces, to the Afghan government, by the end of 2013 at the earliest ? or by the latest as has been agreed upon ? by the end of 2014," Karzai said.
The NATO-led international force in Afghanistan has been steadily handing over responsibility for security to the government's army and police ever since the alliance's last summit in Lisbon in 2010. There, NATO leaders decided to move the Afghans into the lead role in fighting the Taliban by 2014 and end the coalition's combat role.
Afghan forces are already now in the lead if over half of the country's population in terms of security, and the transition process remains on track.
In London, the Ministry of Defense and the Foreign Office had no immediate response to the French proposal. Britain plans to bring its 9,500 troops home by the end of 2014.
Prime Minister David Cameron is due to hold talks with Karzai at his country residence near London on Saturday.
Sarkozy's government has been under political pressure to withdraw French troops before the United States' pegged pullout in 2014. Polls show most French want an early withdrawal.
Francois Heisbourg, an analyst at the Paris-based Foundation for Strategic Research think tank, told The Associated Press this week that a quick exit would also pose logistical problems for French forces, who hope to bring home much of the heavy equipment deployed in Afghanistan.
Francois Hollande, the Socialist nominee for presidential elections this spring, repeated on French TV on Thursday his hope to bring all French forces home this year.
Polls show Hollande leading the conservative Sarkozy, who has not formally announced whether he will run in the two-round election in April and May. Most political observers believe he will.
Nick Witney, a senior policy fellow at the Paris-based European Council on Foreign Relations, said public support of the war in Europe started sliding fast after the coalition agreed to end the combat mission in 2014.
"It has become more and more difficult to justify every single casualty, since it's now clear that these are wasted lives," said Witney, a former head of the European Defense Agency.
"Most European policymakers realize that on a purely cost-benefit assessment, we would all leave Afghanistan tomorrow," Witney said, adding that "it's difficult for any single government to break with its allies without being accused of lack of solidarity."
___
Slobodan Lekic in Brussels, Deb Riechmann in Kabul, Jill Lawless in London and Matthew Lee in Washington contributed to this report.
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On Friday January 20th, Kathy received Cyclophosphamide (Cytoxan) 1200 mg, Doxorubicin (Adriamycin) ?120 mg and her pre-chemotherapy supportive medications Fosaprepitant 150 mg, Dexamethasone 12 mg and Ondansetron 8 mg.
She tolerated it well.
Her Complete Blood Count shows that her Granulocyte Count has dropped from 6690 to 3610 since the chemotherapy affects her fast multiplying white cells as a side effect of targeting the cancer. ? Her hematocrit has fallen from 42 to 32. ? She tires more easily but her appetite is good. ? Small frequent meals enable her to overcome any GI symptoms.
We've been told that the Adriamycin/Cytoxan is the most difficult chemotherapy. ?Only two more cycles to go.
The photograph above shows Kathy and me at age 21 in our Stanford graduation photo. ?She's always had long, luxuriant hair, even a waist length braid at one point.
On January 21st, her hair began falling out in clumps. ? It was not exactly painful, but felt very odd, as if her hair had not been washed in months and just did not lie on her scalp properly. ? In consultation with her cancer survivor friends, she decided to shave it off. ? ?Her hairdresser gave her a "GI Jane" cut realizing that the small hairs left will fall out soon, but in a more manageable and comfortable way. ? ?I seriously considered shaving my head in solidarity, but she asked me not to.
She's wearing wraps and hats to keep her head warm in the chill of winter. ? The colors and shapes of her hats give her an artistic and vibrant look.
Dropping blood counts, lack of energy, and no hair may sound depressing. ? How have we supported her mood?
She's avoided caffeine, alcohol and mood related medications. ?Instead she's remained positive because of the weekly activities we've planned and the future we're designing that goes beyond the statistics of 5 year survival rates.
In my professional life, I've written extensively about SOAP verses REST as standards for transport. ? In my personal life, Kathy and I have explored SOAP as Rest via a course on traditional soap making from Back Porch Soap. ? We've really enjoyed the art and chemistry of saponification, creating our own cold process soaps.
Although we're put our thoughts about Vermont farmland on hold, we've continued to think about how we can move to a more rural location which enables us to plan a long term life together raising ?vegetables and animals as part of self sufficiency, a lower carbon footprint, and sustainability. ?This dream of the future creates a guiding vision for fighting the cancer.
Finally, an interesting experience from our role as patients. ? Kathy has received her care in the middle of the X12 5010 transition which required every payer and provider to change their billing systems. ? Purely as a side effect of a payer eligibility error during the conversion, she received an $18,000 bill for her care to date. ? It was remedied quickly, but it illustrates the events that can occur while navigating healthcare in the US.
Source: http://geekdoctor.blogspot.com/2012/01/our-cancer-journey-week-6.html
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California law requires companies to make clear what they are doing to rid their foreign suppliers from the use forced labor or human trafficking.
January is Human Trafficking Awareness Month, a time to educate people that slavery?exists today and build support for the fight to stop it.
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But this January also happens to be the month that a new law in California has come into effect, the first of its kind in the United States, and one that has the potential to do more than just raise awareness of human trafficking and actually make a real dent in the problem itself.
Human trafficking and forced labor are largely hidden problems, but they persist in just about every country in the world (including in the US) whether it's in cotton fields that feed our demand for clothing or in factories where our electronics are assembled. As consumers, we are all connected to human trafficking and slavery through the goods we use every day.
But a large hurdle in eradicating slavery is how disconnected those final products are from the conditions that produced them.
IN PICTURES: Mumbai laundry workers
The supply chains that companies rely on to bring consumer goods to the market have become so fragmented that a grocery or apparel company has no idea ? sometimes by design, sometimes inadvertently ? that it is enabling the forced exploitation of workers. The retail clothing chain Gap was the target of activist campaigns and got a lot of bad press in the late 1990s for using exploitative child labor in factories that produced Gap clothing. But because stores like Gap outsource labor to factories and do not own them outright (and Gap was never the only one to take this route), they can shirk responsibility for what happens within those facilities.
A new rule in California seeks to put some of that responsibility back into the corporate offices of large businesses, so that it's no longer enough for a company to say it doesn't know the conditions in which its products are grown or manufactured. The California Transparency in Supply Chains Act, which was signed into law last year but only went into effect this month, requires companies to disclose, in a prominent place on their websites, what they are doing to combat forced labor and human trafficking in their supply chains.
The law applies to any manufacturing and retail company with $100 million or more in sales that does business in California; one estimate predicted the law would impact 3,200 global companies. To return to Gap as an example ? in part because a report tailored to the California legislation, Effective Supply Chain Accountability, said Gap has exhibited several model practices in terms of cleaning up its supply chain ? the company created a vendor code of conduct that meets core International Labor Organization standards, followed years later by a human rights policy, and has charted its level of influence over each stage of its supply chain.
Disclosing exactly those types of efforts is what is now required by the new law. A company must indicate the extent to which it audits suppliers for trafficking and slavery, verifies supply chains to evaluate and address risks of human trafficking and whether an independent third party is used for the verification process, maintains internal accountability standards, trains employees on this issue, and certifies that materials used in a product comply with human-trafficking laws in the countries where business is conducted.
There are still some fuzzy points: Certification, for example, has no standard definition. And there is no certifier for slavery-free, the way there is for organic or fair trade. But the law is in effect, companies have started publishing the information necessary to comply ? and they have been advised not to make false or exaggerated claims that misrepresent what they're actually doing. There can be legal consequences.
Source: http://rss.csmonitor.com/~r/feeds/csm/~3/Gyti0Lmp80Q/New-California-law-combats-human-slavery
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RIM's new CEO Thorsten Heins has only been at the reigns for an evening, but he did a very "BlackBerry" job of presenting himself to the media this morning on his introductory media call. It felt a lot like the media calls of yore, with Balsillie and Lazaridis at the helm. Especially when Heins referred to Apple as "the other fruit company," noting the two companies shared strategy of vertical integration. Unfortunately, vertical integration of software and hardware is about all that these two fruits have in common. Remember folks, Heins is coming off of a four-year stint at RIM. At the relatively young company, Heins worked under founder Mike Lazaridis and his partner in crime Jim Balsillie. That said, you can basically hear Lazaridis-style hubris in Heins' comments. When asked if there was anything Heins wanted to do in the past, but was held back from by his position, Heins confirms that he (along with the freshly removed prior leadership) doesn't see much wrong with RIM.Source: http://feedproxy.google.com/~r/Techcrunch/~3/wsYJZRjOrro/
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Reviewed by John M. Grohol, Psy.D. on January 23, 2012
A new study discovers that cancer treatments can significantly hinder the quality of life of younger breast cancer survivors.
Researchers discovered younger women with breast cancer experience a decrease in their health-related quality of life. They also may experience increased psychological distress, weight gain, a decline in their physical activity, infertility and early onset menopause.
The study is published in the Journal of the National Cancer Institute.
Breast cancer is the most common non-skin cancer in women, and is the leading cause of death in women under 50 in the U.S.
Researchers note that although the survival rate for younger women with breast cancer has improved over the last two decades, their cancer treatments, despite their effectiveness, can seriously affect quality of life and other health outcomes.
In the study, researchers sought to determine the impact of cancer treatment on the quality of life of younger breast cancer survivors. Patricia A. Ganz, M.D., and colleagues reviewed studies that focused on overall quality of life, psychosocial effects, menopause and fertility-related concerns, and behavioral outcomes related to weight gain and physical activity.
The studies were published between January 1990 and July 2010. Of the 840 titles and abstracts reviewed, they focused on 28 with the most relevant data.
Investigators found that overall quality of life was compromised in younger breast cancer survivors, with the mental issues more severe than the physical problems.
Depression was also a problem as young women were also more depressed compared to the general age-matched population of women without cancer or women over 50 with breast cancer.
Premature menopause, infertility and menopause-related symptoms were more common and contributing factors to the level of distress in women 50 or younger after treatment.
Weight gain and physical inactivity were common health outcomes in younger women, although exercise rates generally increased after treatment.
Researchers believe the findings demonstrate the need for personalized treatment for breast cancer, especially among young women.
?By tailoring [treatment] and giving cytotoxic therapy only to those who may benefit, we can mitigate some of these side effects, but the long life expectancy for these younger women also provides a window of opportunity for cancer prevention and health promotion activities.?
Source: Journal of the National Cancer Institute
APA Reference
Nauert PhD, R. (2012). Young Breast Cancer Survivors Face Psychological Distress. Psych Central. Retrieved on January 23, 2012, from http://psychcentral.com/news/2012/01/23/young-breast-cancer-survivors-face-psychological-distress/33987.html
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STATE COLLEGE, Pa. ? Happy Valley was perfect for Joe Paterno, a place where "JoePa" knew best, where he not only won more football games than any other major college coach, but won them the right way: with integrity and sportsmanship. A place where character came first, championships second.
Behind it all, however, was an ugly secret that ran counter to everything the revered coach stood for.
Paterno, a sainted figure at Penn State for almost half a century but scarred forever by the child sex abuse scandal that led to his stunning dismissal, died Sunday at age 85.
His death came just 65 days after his son Scott said his father had been diagnosed with a treatable form of lung cancer. The cancer was found during a follow-up visit for a bronchial illness. A few weeks later, Paterno broke his pelvis after a fall but did not need surgery.
Mount Nittany Medical Center said in a statement that Paterno died at 9:25 a.m. of "metastatic small cell carcinoma of the lung." Metastatic indicates an illness that has spread from one part of the body to an unrelated area.
The hospital says Paterno was surrounded by family members, who have requested privacy.
Paterno had been in the hospital since Jan. 13 for observation after what his family called minor complications from his cancer treatments. Not long before that, he conducted his only interview since losing his job, with The Washington Post. Paterno was described as frail then, speaking mostly in a whisper and wearing a wig. The second half of the two-day interview was conducted at his bedside.
His family released a statement Sunday morning to announce his death: "His loss leaves a void in our lives that will never be filled."
"He died as he lived," the statement said. "He fought hard until the end, stayed positive, thought only of others and constantly reminded everyone of how blessed his life had been. His ambitions were far reaching, but he never believed he had to leave this Happy Valley to achieve them. He was a man devoted to his family, his university, his players and his community."
Paterno's death just under three months following his last victory called to mind another coaching great, Alabama's Paul "Bear" Bryant, who died less than a month after retiring.
"Quit coaching?" Bryant said late in his career. "I'd croak in a week."
Paterno alluded to the remark made by his friend and rival, saying in 2003: "There isn't anything in my life anymore except my family and my football. I think about it all the time."
Two police officers were stationed to block traffic on the street where Paterno's modest ranch home stands next to a local park. The officers said the family had asked there be no public gathering outside the house, still decorated with a Christmas wreath, so Paterno's relatives could grieve privately. And, indeed, the street was quiet on a cold winter day.
Paterno's sons, Scott and Jay, arrived separately at the house late Sunday morning. Jay Paterno, who served as his father's quarterbacks coach, was crying.
Paterno built a program based on the credo of "Success with Honor," and he found both. The man known as "JoePa" won 409 games and took the Nittany Lions to 37 bowl games and two national championships. More than 250 of the players he coached went on to the NFL.
"He will go down as the greatest football coach in the history of the game," Ohio State coach Urban Meyer said after his former team, the Florida Gators, beat Penn State 37-24 in the 2011 Outback Bowl.
Paterno roamed the sidelines for 46 seasons, his thick-rimmed glasses, windbreaker and jet-black sneakers as familiar as the Nittany Lions' blue and white uniforms.
The reputation he built looked even more impressive because he insisted that on-field success not come at the expense of high graduation rates.
But in the middle of his 46th season, the legend was shattered. Paterno was engulfed in a child sex abuse scandal when a former trusted assistant, Jerry Sandusky, was accused of molesting 10 boys over a 15-year span, sometimes in the football building.
Outrage built quickly when the state's top cop said the coach hadn't fulfilled a moral obligation to go to the authorities when a graduate assistant, Mike McQueary, told Paterno he saw Sandusky with a young boy in the showers of the football complex in 2002.
At a preliminary hearing for the school officials, McQueary testified that he had seen Sandusky attacking the child with his hands around the boy's waist but said he wasn't 100 percent sure it was intercourse. McQueary described Paterno as shocked and saddened and said the coach told him he had "done the right thing" by reporting the encounter.
Paterno waited a day before alerting school officials and never went to the police.
"I didn't know which way to go ... and rather than get in there and make a mistake," Paterno said in the Post interview.
"You know, (McQueary) didn't want to get specific," Paterno said. "And to be frank with you I don't know that it would have done any good, because I never heard of, of, rape and a man. So I just did what I thought was best. I talked to people that I thought would be, if there was a problem, that would be following up on it."
When the scandal erupted in November, Paterno said he would retire following the 2011 season. He also said he was "absolutely devastated" by the abuse case.
"This is a tragedy," he said. "It is one of the great sorrows of my life. With the benefit of hindsight, I wish I had done more."
But the university trustees fired Paterno, effective immediately. Graham Spanier, one of the longest-serving university presidents in the nation, also was fired.
Paterno was notified by phone, not in person, a decision that board vice chairman John Surma regretted, trustees said. Lanny Davis, the attorney retained by trustees as an adviser, said Surma intended to extend his regrets over the phone before Paterno hung up him.
After weeks of escalating criticism by some former players and alumni about a lack of transparency trustees last week said they fired Paterno in part because he failed a moral obligation to do more in reporting the 2002 allegation.
An attorney for Paterno on Thursday called the board's comments self-serving and unsupported by the facts. Paterno fully reported what he knew to the people responsible for campus investigations, lawyer Wick Sollers said.
"He did what he thought was right with the information he had at the time," Sollers said.
The university handed the football team to one of Paterno's assistants, Tom Bradley, who said Paterno "will go down in history as one of the greatest men, who maybe most of you know as a great football coach."
"As the last 61 years have shown, Joe made an incredible impact," said the statement from the family. "That impact has been felt and appreciated by our family in the form of thousands of letters and well wishes along with countless acts of kindness from people whose lives he touched. It is evident also in the thousands of successful student athletes who have gone on to multiply that impact as they spread out across the country."
New Penn State football coach Bill O'Brien, hired earlier this month, offered his condolences.
"The Penn State Football program is one of college football's iconic programs because it was led by an icon in the coaching profession in Joe Paterno," O'Brien said in a statement. "There are no words to express my respect for him as a man and as a coach. To be following in his footsteps at Penn State is an honor. Our families, our football program, our university and all of college football have suffered a great loss, and we will be eternally grateful for Coach Paterno's immeasurable contributions."
Paterno believed success was not measured entirely on the field. From his idealistic early days, he had implemented what he called a "grand experiment" ? to graduate more players while maintaining success on the field.
"He maintained a high standard in a very difficult profession. Joe preached toughness, hard work and clean competition," Sandusky said in a statement. "Most importantly, he had the courage to practice what he preached."
Paterno was a frequent speaker on ethics in sports, a conscience for a world often infiltrated by scandal.
The team consistently ranked among the best in the Big Ten for graduating players. As of 2011, it had 49 academic All-Americans, the third-highest among schools in the Football Bowl Subdivision. All but two played under Paterno.
"He teaches us about really just growing up and being a man," former linebacker Paul Posluszny, now with the NFL's Jacksonville Jaguars, once said. "Besides the football, he's preparing us to be good men in life."
Paterno certainly had detractors. One former Penn State professor called his high-minded words on academics a farce, and a former administrator said players often got special treatment. His coaching style often was considered too conservative. Some thought he held on to his job too long, and a move to push him out in 2004 failed.
But the critics were in the minority, and his program was never cited for major NCAA violations. The child sex abuse scandal, however, did prompt separate inquiries by the U.S. Department of Education and the NCAA into the school's handling.
Paterno played quarterback and defensive back for Brown University and set a defensive record with 14 career interceptions, a distinction he still boasted about to his teams in his 80s. He graduated in 1950 with plans to go to law school. He said his father hoped he would someday be president.
But when Paterno was 23, a former coach at Brown was moving to Penn State to become the head coach and persuaded Paterno to come with him as an assistant.
"I had no intention to coach when I got out of Brown," Paterno said in 2007 in an interview at Penn State's Beaver Stadium before being inducted into college football's Hall of Fame. "Come to this hick town? From Brooklyn?"
In 1963, he was offered a job by the late Al Davis ? $18,000, triple his salary at Penn State, plus a car to become general manager and coach of the AFL's Oakland Raiders. He said no. Rip Engle retired as Penn State head coach three years later, and Paterno took over.
At the time, Penn State was considered "Eastern football" ? inferior ? and Paterno courted newspaper coverage to raise the team's profile. In 1967, PSU began a 30-0-1 streak.
But Penn State couldn't get to the top of the polls. The Nittany Lions finished second in 1968 and 1969 despite perfect seasons. They were undefeated and untied again in 1973 at 12-0 again but finished fifth. Texas edged them in 1969 after President Richard Nixon, impressed with the Longhorns' bowl performance, declared them No. 1.
"I'd like to know," Paterno said later, "how could the president know so little about Watergate in 1973, and so much about college football in 1969?"
A national title finally came in 1982, after a 27-23 win over Georgia at the Sugar Bowl. Another followed in 1986 after the Lions intercepted Vinny Testaverde five times and beat Miami 14-10 in the Fiesta Bowl.
They made several title runs after that, including a 2005 run to the Orange Bowl and an 11-1 season in 2008 that ended in a 37-23 loss to Southern California in the Rose Bowl.
In his later years, physical ailments wore the old coach down.
Paterno was run over on the sideline during a game at Wisconsin in November 2006 and underwent knee surgery. He hurt his hip in 2008 demonstrating an onside kick. An intestinal illness and a bad reaction to antibiotics prescribed for dental work slowed him for most of the 2010 season. He began scaling back his speaking engagements that year, ending his summer caravan of speeches to alumni across the state.
Then a receiver bowled over Paterno at practice in August, sending him to the hospital with shoulder and pelvis injuries and consigning him to coach much of what would be his last season from the press box.
"The fact that we've won a lot of games is that the good Lord kept me healthy, not because I'm better than anybody else," Paterno said two days before he won his 409th game and passed Eddie Robinson of Grambling State for the most in Division I. "It's because I've been around a lot longer than anybody else."
Paterno could be conservative on the field, especially in big games, relying on the tried-and-true formula of defense, the running game and field position.
He and his wife, Sue, raised five children in State College. Anybody could telephone him at his home ? the same one he appeared in front of on the night he was fired ? by looking up "Paterno, Joseph V." in the phone book.
He walked to home games and was greeted and wished good luck by fans on the street. Former players paraded through his living room for the chance to say hello. But for the most part, he stayed out of the spotlight.
Paterno did have a knack for jokes. He referred to Twitter, the social media site, as "Twittle-do, Twittle-dee."
He also could be abrasive and stubborn, and he had his share of run-ins with his bosses or administrators. And as his legend grew, so did the attention to his on-field decisions, and the questions about when he would hang it up.
Calls for his retirement reached a crescendo in 2004. The next year, Penn State went 11-1 and won the Big Ten. In the Orange Bowl, PSU beat Florida State, whose coach, Bobby Bowden, was eased out after the 2009 season after 34 years and 389 wins.
Like many others, he was outlasted by "JoePa."
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What is an Android launcher? Probably the most powerful feature of Android is its ability to be customized. And that starts with what's typically called the "launcher." The launcher usually is considered to be the homescreens and app drawer, and they come in all sorts of flavors and designs.
When you hear people talk about "stock" Android, this usually is what they're referring to -- homescreens and launcher unchanged from what Google includes in the open-sourced code. But that's just the tip of the iceberg. From there, you can download any number of third-party "launchers," which will change the look and functionality of the homescreens and the app drawer. Home screens can have different animations. Or different docks at the bottom. Or a specific number of home screens. App drawers can have more scrolling or sorting options. The possibilities might not be endless, but they're certainly numerous.
Google has included a lot of improvements in the Ice Cream Sandwich launcher, but third-party apps absolutely are not yet obsolete.) Some of the more popular third-party launchers include:
There is no shortage of third-party launchers. But they're not the only ones. Smartphone manufacturers all have their own launchers, too. HTC has its Sense UI, its own homescreen and its own app drawer, all nicknamed "Rosie." Motorola has long has its "Blur" user interface. Samsung has "TouchWiz." Don't like any of them? You can install a third-party launcher on top of the default user interface. And with as powerful as today's phones are, you can do so without any real degradation in performance.
Previously on Android A to Z: What is a kernel?; Find more in the Android Dictionary
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Source: http://feedproxy.google.com/~r/androidcentral/~3/QGTzujnRf_A/story01.htm
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The tree collapsed into my yard causing my grill and table umbrella to break, also broke the fence. He had the tree removed and repaired the fence but who pays for my broken stuff. The neighbor is saying that my homeowners insurance pays but shouldnt?s it be his???
Call your insurance ASAP.
If the neighbor?s tree fell due to their own negligence (the tree was dead and rotted out but they failed to remove it, etc) then it is their responsibility. If the tree fell because of a storm or other act of God than your insurance should pay.
Either way, this is for the insurance companies to work out. So call your agent, explain the situation, and let them work it out.
by: Boston
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Continue reading Researchers turn your smartphone into a virtual projector
Researchers turn your smartphone into a virtual projector originally appeared on Engadget on Sun, 22 Jan 2012 12:37:00 EDT. Please see our terms for use of feeds.
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WASHINGTON ? In an election-year decision certain to disappoint religious conservatives, the Obama administration announced Friday that church-affiliated institutions will get only one additional year to meet a new rule to cover birth control free of charge.
Friday's announcement by Health and Human Services Secretary Kathleen Sebelius does not apply to houses of worship. Churches, synagogues, mosques and other places of worship were already exempt from the birth control coverage rule.
But in many cases, other religious-affiliated employers such as hospitals and universities traditionally have not provided any birth control coverage for their employees. They were seeking a broader exemption that would allow them to continue that practice.
The new rule is part of a package of improved preventive services for women under President Barack Obama's health care overhaul. Birth control is on a list of services that most workplace health plans will have to cover free of charge to employees.
Instead, the one-year extension applies to nonprofit institutions such as church-affiliated hospitals, universities and social service organizations. They will now have until August 1, 2013, to comply. Because of the way health insurance plans work, their employees will not have access to the new coverage until January 1, 2014, in most cases.
Birth control use is virtually universal in the United States, and most employer health plans already cover it, usually with copays for employees. Last year, an advisory panel from the prestigious Institute of Medicine recommended that the government require birth control coverage as preventive care under Obama's law, meaning it would become available free of charge.
Sebelius quickly agreed, issuing a new federal regulation.
But religious groups complained that a conscience exemption included in that rule was too narrowly written. Catholic hospitals, which defied the bishops to support passage of Obama's health care law in Congress, were among those who objected.
Sebelius said her decision Friday was carefully considered.
"I believe this proposal strikes the appropriate balance between respecting religious freedom and increasing access to important preventive services," Sebelius said in a statement.
Nonetheless, conservatives in Congress are already pursuing legislation to try to block the regulation. And Republican presidential candidates say they would derail it also, by repealing the health care law if elected.
For most American women, the birth control coverage requirement will take effect sooner. Employer health plans in most cases have to comply by August of this year. Because of the time involved in adding new coverage, that means the majority of women will be able to receive free birth control coverage starting January 1, 2013.
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Ice Cream Sandwich update for original Transformer coming 'mid-February,' says ASUS originally appeared on Engadget on Sat, 21 Jan 2012 15:15:00 EDT. Please see our terms for use of feeds.
Permalink |ASUS (Facebook) | Email this | CommentsSource: http://www.engadget.com/2012/01/21/ice-cream-sandwich-update-for-original-transformer-coming/
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>>> depending on what you searched for on the web today you either got what you wanted or drove right into a black hole as some sites took themselves down to send a message to all of us wanting to imagine a world without free knowledge. new media on the web ran up against older schooled media in this case, including the company we work for, in a fight over a bill aimed at preventing internet piracy . critics say it will lead somehow to censorship. nbc 's kevin tibbles reports.
>> reporter: wikipedia pulled the plug for 24 hours to protest the sofa before congress.
>> this bill puts together the infrastructure for censorship in a way completely unnecessary to combat piracy.
>> reporter: those in the industry supporting regulation including nbc universal claim online piracy costs $135 billion a year and steals 2.5 million jobs worldwide.
>> your father's counterfeit was people selling cheap knockoffs on street corners. today those same criminal enterprises sell these products online, dupe consumers.
>> reporter: they aim to block foreign websites that infringe on copyrights from movies and television, music, publishing, software and consumer products , even material on youtube could be affected. not so long ago much of our information came from these, but in the last decade or so the proliferation of the internet has made ownership of this information very difficult to police. but the online revolt against sopa has grown to include some 7,000 websites, including the tech site wired, boing boing and mozilla, maker of the popular browser firefox. google blacked out its own familiar home page adding the message "tell congress please don't censor the web." here's nbc 's kelly o'donnell.
>> reporter: democrats and republicans have been bombarded with calls and e-mails and many are backing off.
>> reporter: ask any group of college kids and they'll tell you.
>> a lot of people think why pay for it.
>> if the price is too outrageous it will probably get pirated.
>> reporter: it didn't take long to discover hitting escape reopens the wikipedia site. these days information travels fast. kevin tibbles, nbc news, chicago.
Source: http://video.msnbc.msn.com/nightly-news/46047529/
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